Mark Hyman, MD

A neuroscientist analyzed 200,000 brain scans to identify the single root cause behind declining brain health. Today, I’m talking with neuroscientist Paul Thompson, PhD, whose work with the global ENIGMA Consortium is revealing how brain health connects to what’s happening throughout your body. We often treat symptoms of mental fatigue or memory loss in isolation, but looking at the big picture reveals a different story. By examining the data from a massive set of brain scan results, we can see how lifestyle choices directly impact long-term cognitive function. Understanding these patterns is the first step toward protecting your mind from age-related decline. This conversation explores what the neuroscientist discovered across thousands of patients and how you can apply these findings to your own routine. Whether you are focused on sharpening your focus or supporting your overall mental wellness, addressing the foundational factors is essential. Small, consistent changes to your daily habits can stabilize your biology and support lasting clarity. We discuss: - What your “brain age” means and how it can differ from your actual age - Why your metabolic health deserves attention when you’re struggling with mood or memory - How sleep and nutrition support your brain’s ability to function and recover - What having an Alzheimer’s risk gene does, and doesn’t, tell you about your future - How brain scans, blood tests, and AI could help identify the right treatment for you It’s so exciting to see researchers like Paul looking across thousands of brain scans and uncovering connections between the health of the body and the brain. For me, it opens up a bigger conversation about how we care for ourselves and how our everyday habits can help protect our memory and support our mood as we age. #BrainHealth #ReverseAging #Neuroscience #AlzheimersPrevention #MarkHyman View Show Notes From This Episode - https://drhyman.com/blogs/content/podcast-ep1188 Sign up for Dr. Hyman’s Brainshaping Academy to learn how to nourish the biological systems that support your mental, emotional, and cognitive health https://drhyman.com/products/brainshaping?utm_source=dr_hyman_show&utm_medium=newsletter&utm_campaign=may_27&utm_content=link Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, Paleovalley, Timeline, Seed, BIOptimizers, and Fatty15. Explore red light products at https://boncharge.com/hyman and enjoy 15% off with code HYMAN. Shop nutrient-rich foods and supplements at https://paleovalley.com/hyman and save 15% off your first order. Support healthy aging and get up to 20% off when you subscribe on top of the new starting price of $79 at https://timeline.com/drhyman. Make your microbiome part of your daily routine with https://seed.com/hyman and save 25% with code 25HYMAN. Use https://bioptimizers.com/hyman and code HYMAN for 15% off, special bonuses, and a 365-day money-back guarantee. Head to https://fatty15.com/HYMAN today and use code HYMAN for 15% off your 90-day subscription Starter Kit. 0:00 Brain Health Beyond Symptoms 4:43 Alzheimer’s Patterns in Brain Scans 9:18 Functional Imaging Changes Psychiatry 16:41 Treating the Body to Heal Brain 23:16 Depression and Compulsion Networks 27:17 How Functional MRI Works 29:31 Brain Age and Lifestyle Factors 35:03 Sleep, Nutrition, and Recovery 40:32 Resting Networks and Brain Balance 51:00 Genes, Risk, and Precision Medicine 57:43 Brain Imaging and Biomarkers 1:09:56 Psychiatry, Proteomics, and AI